Intermittent parathyroid hormone (1-34) supplementation of bone marrow stromal cell cultures may inhibit hypertrophy, but at the expense of chondrogenesis.

Ena MusicKathryn FutregaJames S PalmerMackenzie KinneyBill LottTravis J KleinMichael Robert Doran

Published in: Stem cell research & therapy (2020)

This study provides further clarity on the role of PTH on chondrogenic differentiation in vitro and suggests that while PTH may mitigate BMSC hypertrophy, it does so at the expense of chondrogenesis.

Keyphrases

bone marrow
mesenchymal stem cells
single cell
cell therapy
high intensity
stem cells