Efficacy of Inclisiran in patients having familial hypercholesterolemia: heterozygous compared to homozygous trait, a systematic review and meta analysis.

Rahul RaiPayal DeviKapeel KumarKainat NaeemHanesh KumarKajal KumariAnish KumarAman KumarAqeel MuhammadMuhammad Sohaib KhanGhulam QadirShaheryar AliMahveer MaheshwariMuhammad Jawwad

Published in: Critical pathways in cardiology (2024)

There was significant difference in the reductions in atherosclerotic lipid parameters in heterozygous and homozygous populations after the administration of Inclisiran except for PCSK9 parameter. Further studies are needed to support this conclusion.

Keyphrases

end stage renal disease
early onset
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
gene expression
dna methylation