Angiotensin II-Mediated Neuroinflammation in the Hippocampus Contributes to Neuronal Deficits and Cognitive Impairment in Heart Failure Rats.
Ferdinand AlthammerRanjan K RoyMatthew K KirchnerElba Campos-LiraKathryn E WhitleySteven DavisJuliana MontanezHildebrando Candido Ferreira-NetoJessica DanhRafaela G FeresinVinicia Campana BiancardiUsama ZafarMarise B ParentJavier E SternPublished in: Hypertension (Dallas, Tex. : 1979) (2023)
In this study, we identified a neuronal substrate (hippocampus), a mechanism (Ang II-driven neuroinflammation) and a potential neuroprotective therapeutic target (AT1aRs) for the treatment of cognitive deficits in HF.
Keyphrases
- cerebral ischemia
- angiotensin ii
- cognitive impairment
- subarachnoid hemorrhage
- heart failure
- blood brain barrier
- brain injury
- vascular smooth muscle cells
- angiotensin converting enzyme
- traumatic brain injury
- acute heart failure
- lipopolysaccharide induced
- left ventricular
- prefrontal cortex
- inflammatory response
- climate change
- lps induced