Dissecting signaling regulators driving AXL-mediated bypass resistance and associated phenotypes by phosphosite perturbations.

Marc CreixellScott D TaylorJacqueline GerritsenSong Yi BaeMingxuan JiangTeresa AugustinMichelle LouiCarmen BoixoPau CreixellForest M WhiteAaron S Meyer

Published in: bioRxiv : the preprint server for biology (2023)

A systems biology approach elucidates the signaling pathways driving AXL-mediated erlotinib resistance in lung cancer.

Keyphrases

tyrosine kinase
signaling pathway
epidermal growth factor receptor
transcription factor
advanced non small cell lung cancer
cell proliferation
oxidative stress
endoplasmic reticulum stress