Risk Factors for Psoriasis Flares: A Narrative Review.
Luca PotestioGiuseppe LaulettaNello TommasinoAntonio PortarapilloAntonia SalsanoTeresa BattistaFabrizio MartoraMatteo MegnaPublished in: Psoriasis (Auckland, N.Z.) (2024)
Psoriasis is a chronic inflammatory cutaneous disease with multifactorial pathogenesis involving both genetic and environmental factors as well as the innate and acquired immune response. Several triggering factors may exacerbate or worsen the disease. In this context, we performed a review manuscript with the aim of investigating current literature on psoriasis risk factors, also showing possible mechanisms by which they act on psoriasis. Globally, risk factors can be divided in classic risk factors (eg, mechanical stress, infections and dysbiosis of the skin, common drugs, environment and pollution, lifestyle, psychological stress, hormonal and metabolic alterations) which have long been known to be responsible for worsening and/or reoccurrence of psoriatic manifestations, and emerging risk factors (eg, biological drugs, immunotherapy for oncologic disease, Covid-19, and vaccines) defined as those newly identified risk factors. Accurate patient information and monitoring of risk factors as well as planned follow-ups may help to prevent and treat the worsening of psoriasis and consequently improve the quality of life of psoriatic patients.
Keyphrases
- risk factors
- immune response
- rheumatoid arthritis
- end stage renal disease
- coronavirus disease
- sars cov
- type diabetes
- cardiovascular disease
- prostate cancer
- ankylosing spondylitis
- risk assessment
- chronic kidney disease
- metabolic syndrome
- oxidative stress
- adipose tissue
- weight loss
- inflammatory response
- insulin resistance
- atopic dermatitis
- peritoneal dialysis
- mass spectrometry
- prognostic factors
- climate change
- disease activity
- sleep quality
- rectal cancer
- social media
- patient reported outcomes