β-Sitosterol Alters the Inflammatory Response in CLP Rat Model of Sepsis by Modulation of NFκB Signaling.
Sara KasirzadehMohammad Hossein GhahremaniNeda SetayeshFereshteh JeivadAmir ShadboorestanAli TaheriAbbas Beh-PajoohArmin Azadkhah ShalmaniAlireza Ebadollahi-NatanziAlamgir KhanSamin SabzevariOmid SabzevariPublished in: BioMed research international (2021)
βS may play a protective role in the septic process by mitigating inflammation. This effect is at least partly mediated by inhibition of the NF-κB signaling pathway. Thus, βS can be considered as a supplementary treatment in septic patients.
Keyphrases
- signaling pathway
- inflammatory response
- acute kidney injury
- lps induced
- pi k akt
- oxidative stress
- end stage renal disease
- ejection fraction
- newly diagnosed
- intensive care unit
- epithelial mesenchymal transition
- prognostic factors
- lipopolysaccharide induced
- toll like receptor
- septic shock
- endoplasmic reticulum stress