Trimethoprim-sulfamethoxazole as de-escalation in ventilator-associated pneumonia: a cohort study subanalysis.
Alessio StrazzullaMaria Concetta PostorinoTracie YoubongMaxence RouyerClara FlateauCatherine ChakvetadzeAstrid de PontfarcyAurelia PitschSebastien JochmansNabil BelfekiMehran MonchiSylvain DiamantisPublished in: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (2021)
De-escalation to TMP-SMX for VAP treatment was not associated with higher mortality at EoT and T30 than standard treatment with β-lactam. Monotherapy with TMP-SMX as de-escalation from broad-spectrum empirical regimens is a β-lactam sparing strategy worthy to be further investigated in either multicenter cohort studies or randomized clinical trials.