The Role of the Spinal Wnt Signaling Pathway in HIV-Related Neuropathic Pain.
Jian HuangChris Bloe BloeXinxin ZhouShengjun WuWenping ZhangPublished in: Cellular and molecular neurobiology (2020)
Human immunodeficiency virus (HIV)-related neuropathic pain includes HIV-induced neuropathic pain (HNP) and antiretroviral therapy-induced neuropathic pain (ART-NP). A significant amount of evidence from the past few years has shown that the development of HIV-related neuropathic pain is closely related to the activation of the Wnt signaling pathway in the spinal cord. This review summarizes the function of the spinal Wnt signaling pathway in HIV-induced neuropathic pain, focusing on the role of the spinal Wnt signaling pathway in HNP, and provides a theoretical basis for further studies and the exploration of new target drugs.
Keyphrases
- neuropathic pain
- antiretroviral therapy
- spinal cord
- human immunodeficiency virus
- hiv infected
- hiv positive
- signaling pathway
- spinal cord injury
- hiv aids
- hiv infected patients
- hepatitis c virus
- pi k akt
- hiv testing
- cell proliferation
- diabetic rats
- stem cells
- drug induced
- high glucose
- epithelial mesenchymal transition
- men who have sex with men
- oxidative stress
- induced apoptosis