Indoxyl sulfate exacerbates alveolar bone loss in chronic kidney disease through ferroptosis.

Huiwen ChenYining ZhouYingli LiuWei ZhouLina XuDihua ShangJing NiZhongchen Song

Published in: Oral diseases (2024)

IS activated the AhR/SLC7A11/GPX4 signaling pathway, inhibited osteogenesis in MC3T3-E1 cells, and participated in alveolar bone resorption in CKD model mice through ferroptosis.

Keyphrases

bone loss
induced apoptosis
cell death
signaling pathway
cell cycle arrest
pi k akt
chronic kidney disease
endoplasmic reticulum stress
epithelial mesenchymal transition
high fat diet induced
oxidative stress
bone mineral density
adipose tissue
metabolic syndrome