LncRNA PVT1 triggers Cyto-protective autophagy and promotes pancreatic ductal adenocarcinoma development via the miR-20a-5p/ULK1 Axis.

Fengting HuangWenying ChenJuanfei PengYuanhua LiYanyan ZhuangZhe ZhuChunkui ShaoWanling YangHerui YaoShineng Zhang

Published in: Molecular cancer (2018)

The present study demonstrates that the "PVT1/miR-20a-5p/ULK1/autophagy" pathway modulates the development of pancreatic ductal adenocarcinoma and may be a novel target for developing therapeutic strategies for pancreatic ductal adenocarcinoma.

Keyphrases

cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
long non coding rna