Critical contribution of mitochondria in the development of cardiomyopathy linked to desmin mutation.

Yeranuhi HovhannisyanZhenlin LiDomitille CallonRodolphe SuspèneVivien BatoumeniAlexis CanetteJocelyne BlancHakim HociniCécile LefebvreNora El-JahraniMaria KitsaraAurore L'honoréEkaterini KordeliPaul FornesJean-Paul ConcordetGérard TachdjianAnne-Marie RodriguezJean-Pierre VartanianAnthony BéhinKarim WahbiPierre JoanneOnnik Agbulut

Published in: Stem cell research & therapy (2024)

mutation, demonstrates the crucial role of mitochondrial abnormalities in the pathophysiology of desmin-related cardiomyopathy, and opens up new potential therapeutic perspectives for this disease.

Keyphrases

heart failure
oxidative stress
cell death
reactive oxygen species
atrial fibrillation