Drug Efficacy Comparison of pH-Sensitive and Non-pH-Sensitive Taxol Delivery Nanoparticles in Cancer Therapy.

Taxol is one of the most widely used chemotherapeutic agents but is restricted by its poor solubility and severe side effects in clinical practice. To overcome these limitations, pH-sensitive nanoparticles, Acetalated Dextran 6k -PEG 5k -PLA 2k -Taxol (ADPP-PTX) and non-pH-sensitive nanoparticles, Propionic Anhydride modified Dextran 6k -PEG 5k -PLA 2k -Taxol (PDPP-PTX) were developed for the delivery of Taxol. Compared with PDPP-PTX, ADPP-PTX showed higher sensitivity to acid response and a greater anti-proliferative effect on cancer cells. In the in vivo study, ADPP-PTX treatment effectively suppressed the growth of tumors, while only half the dose of Taxol was used, which significantly reduced systemic toxicity compared with Taxol and PDPP-PTX. This article is protected by copyright. All rights reserved.