Identification of cell-specific differential DNA methylation associated with methotrexate treatment response in rheumatoid arthritis.
Cameron AdamsNisha NairDarren PlantSuzanne M M VerstappenHong L QuachDiana L QuachAlex CarvidiJoanne NitithamMary NakamuraJonathan GrafAnne BartonLindsey A CriswellLisa F BarcellosPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2023)
We identified cell-specific changes in DNAm associated with MTX response in RA patients. Future studies of DNAm and MTX response should include measurements of DNAm from sorted cells.
Keyphrases
- rheumatoid arthritis
- dna methylation
- end stage renal disease
- single cell
- cell therapy
- newly diagnosed
- nk cells
- chronic kidney disease
- ejection fraction
- induced apoptosis
- gene expression
- peritoneal dialysis
- high dose
- genome wide
- cell cycle arrest
- low dose
- endoplasmic reticulum stress
- idiopathic pulmonary fibrosis
- patient reported