Insulin Secretory Capacity and Insulin Resistance in Korean Type 2 Diabetes Mellitus Patients.
Jong Dai KimWon Young LeePublished in: Endocrinology and metabolism (Seoul, Korea) (2016)
It is well known that many Korean patients with type 2 diabetes mellitus (T2DM) were non-obese and had decreased insulin secretion in past. However, during the past three decades, lifestyles in Korea have been westernized. As a result, the prevalence of obesity, the main cause of diabetes has increased. Thus, there is still a question as to whether the main pathophysiology of current Korean T2DM is insulin resistance or an insulin secretion defect. Because various anti-diabetes medications having different mechanisms of action are currently used as therapeutics, it is important to understand which of these factors is the main physiology in the development of diabetes in Koreans. In this review, we review changes in obesity prevalence, insulin resistance and insulin secretion defects in Korean T2DM during three decades.
Keyphrases
- glycemic control
- insulin resistance
- type diabetes
- weight loss
- adipose tissue
- metabolic syndrome
- high fat diet induced
- high fat diet
- skeletal muscle
- polycystic ovary syndrome
- end stage renal disease
- bariatric surgery
- ejection fraction
- newly diagnosed
- cardiovascular disease
- peritoneal dialysis
- weight gain
- small molecule
- prognostic factors
- cardiovascular risk factors
- patient reported outcomes