Copper-Catalyzed Bromo-cyanomethylative Cyclization of Enynes.
Shaoqun ZhuYingjie PanYue SunXiaoyan HongXiaoyun ChenYing HanChao-Guo YanYaocheng ShiHong HouPublished in: The Journal of organic chemistry (2022)
A copper-catalyzed bromo-cyanomethylative cyclization of 1,6-enynes is demonstrated. The treatment of 2-bromoacetonitrile with CuI enables the alkyl radical generation and triggers the radical addition/cyclization/bromination sequence, giving various vinyl C-Br bonds containing functionalized heterocycles in good yields.