Optimizing maintenance therapy in acute myeloid leukemia: where do we stand in the year 2024?

Patients withFLT3-positive AML should receive midostaurin or quizartinib in the first-linesetting. For a patient initially receiving midostaurin, consider switching tosorafenib in the post-transplant setting. Because of the improved safetyprofile and potency, many experts will lean toward using a second-generationFLT3 inhibitor such as quizartinib or gilteritinib. Finally, no data indicatewhether maintenance therapy should be prolonged until progression or for adefined period.