Beta-Blocker Use in Pregnancy and Risk of Specific Congenital Anomalies: A European Case-Malformed Control Study.

Jorieke Elisabertha Hermina BergmanL Renée LutkeRijk O B GansMarie-Claude AddorIngeborg BarisicClara Cavero-CarbonellEster GarneMiriam GattKari KlungsoyrNathalie LelongCatherine LynchOlatz MokoroaVera NelenAmanda J NevilleAnna PieriniHanitra RandrianaivoAnke RissmannDavid TuckerAwi WieselHelen DolkMaria LoaneMarian Karolien Bakker

Published in: Drug safety (2018)

Beta-blocker use in the first trimester of pregnancy was not found to be associated with a higher risk of specific congenital anomalies in the offspring, but a new signal between alpha- and beta-blockers and multi-cystic renal dysplasia was found. Future large epidemiological studies are needed to confirm or refute our findings.

Keyphrases

angiotensin converting enzyme
preterm birth
pregnancy outcomes
current status
adipose tissue
metabolic syndrome
case control
skeletal muscle
insulin resistance