Non-resolving neuroinflammation regulates axon regeneration in chronic spinal cord injury.

Andrew N StewartChristopher C Bosse-JosephReena KumariWilliam M BaileyKennedy A ParkVictoria K SloneJohn C Gensel

Published in: bioRxiv : the preprint server for biology (2024)

Macrophages and microglia repopulate the chronically injured spinal cord after depletion.CSF1R antagonism in chronic SCI augments the growth of specific axon types in the lesion.CSF1R antagonism does not augment a PTEN-knockout-induced functional recovery.

Keyphrases

spinal cord injury
spinal cord
neuropathic pain
stem cells
drug induced
inflammatory response
traumatic brain injury
cell proliferation
high glucose
lipopolysaccharide induced
lps induced
cognitive impairment
pi k akt
oxidative stress
cerebrospinal fluid
endothelial cells
blood brain barrier
wound healing
wild type