Risk Stratification Before Living Donor Kidney Transplantation in Patients With Preformed Donor-specific Antibodies by Different Crossmatch Methods.
Malte ZiemannMonika LindemannMichael HallenslebenWolfgang AltermannKarina AlthausKlemens BuddeGunilla EineckeUte EisenbergerAndrea EnderThorsten FeldkampFlorian GrahammerMartina GuthoffChristopher Holzmann-LittigChristian HugoTeresa KaukeStephan KemmnerMartina KochNils LachmannMatthias MargetChristian MorathMartin NitschkeLutz RendersSabine SchererJulian StumpfVedat SchwengerFlorian SommerBernd SpriewaldCaner SüsalDaniel ZecherFalko M HeinemannMurielle VerboomPublished in: Transplantation direct (2024)
Especially FXM are useful for risk stratification, as the outcome of DSA-positive, FXM-negative patients is similar to that of DSA-negative patients, whereas FXM-positive patients have both more AMR and decreased 10yGS. Because of their lower sensitivity, the significance of Luminex-based crossmatches, C1qXM, and C3dXM would have to be examined in patients with stronger DSA.