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MiR-302d inhibits TGFB-induced EMT and promotes MET in primary human RPE cells.

Xiaonan HuMaximilian BinterKarsten HufendiekJan TodeCarsten FrammeHeiko Fuchs
Published in: PloS one (2022)
The protective effect of miR-302d might be a promising approach for ameliorating retinal fibrosis and neovascularization. MiR-302d suppresses TGFB-induced EMT in hRPE cells via downregulation of TGFBR2, even reversing the process. Furthermore, miR-302d reduces the constitutive secretion of VEGFA from hRPE cells.
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