B Cell Lymphoma 2: A Potential Therapeutic Target for Cancer Therapy.
Manzar AlamSabeeha AliTaj MohammadGulam Mustafa HasanDharmendra Kumar YadavM D Imtaiyaz HassanPublished in: International journal of molecular sciences (2021)
Defects in the apoptosis mechanism stimulate cancer cell growth and survival. B cell lymphoma 2 (Bcl-2) is an anti-apoptotic molecule that plays a central role in apoptosis. Bcl-2 is the founding constituent of the Bcl-2 protein family of apoptosis controllers, the primary apoptosis regulators linked with cancer. Bcl-2 has been identified as being over-expressed in several cancers. Bcl-2 is induced by protein kinases and several signaling molecules which stimulate cancer development. Identifying the important function played by Bcl-2 in cancer progression and development, and treatment made it a target related to therapy for multiple cancers. Among the various strategies that have been proposed to block Bcl-2, BH3-mimetics have appeared as a novel group of compounds thanks to their favorable effects on many cancers within several clinical settings. Because of the fundamental function of Bcl-2 in the regulation of apoptosis, the Bcl-2 protein is a potent target for the development of novel anti-tumor treatments. Bcl-2 inhibitors have been used against several cancers and provide a pre-clinical platform for testing novel therapeutic drugs. Clinical trials of multiple investigational agents targeting Bcl-2 are ongoing. This review discusses the role of Bcl-2 in cancer development; it could be exploited as a potential target for developing novel therapeutic strategies to combat various types of cancers. We further highlight the therapeutic activity of Bcl-2 inhibitors and their implications for the therapeutic management of cancer.
Keyphrases
- papillary thyroid
- oxidative stress
- squamous cell
- cell death
- endoplasmic reticulum stress
- clinical trial
- childhood cancer
- lymph node metastasis
- squamous cell carcinoma
- drug delivery
- cell proliferation
- diffuse large b cell lymphoma
- amino acid
- protein protein
- transcription factor
- signaling pathway
- binding protein
- single cell
- smoking cessation
- drug induced