Prediction of neuropathologic lesions from clinical data.

Thanaphong PhongpreechaBrenna CholertonSyed BhukariAlan L ChangDavide De FrancescoMelan ThuraiappahDana GodrichAmalia PernaMartin G BeckerNeal G RavindraCamilo EspinosaYeasul KimEloise BersonSamson MatarasoSharon J ShaEdward J FoxKathleen S MontineLaura D BakerSuzanne CraftLon WhiteKathleen L PostonGary BeechamNima AghaeepourThomas J Montine

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)

Certain clinical features could be strongly associated with multiple neurodegenerative diseases, others were lesion-specific, and some were divergent between lesions. Our approach could benefit clinical research, and genetic and biomarker research by enriching cohorts for desired lesions.

Keyphrases

gene expression
copy number
dna methylation