A systematic review and meta-analysis of prospective studies on obesity and risk of inflammatory bowel disease.
Alireza MilajerdiFatemeh AbbasiAhmad EsmaillzadehPublished in: Nutrition reviews (2021)
Overall, 9 studies were included. Combining findings from 5 studies, a statistically significant 21% lower risk of ulcerative colitis incidence was found in patients with obesity than in those with normal weight (RR, 0.79; 95% CI, 0.68-0.92; I2= 0.0%), but not with risk of ulcerative colitis exacerbation, as found by meta-analysis of 3 studies. Pooling data from 5 studies, no significant differences were seen in the risk of Crohn's disease incidence between patients in the highest range of BMI and those in the normal range. In addition, no significant nonlinear association was found between BMI and risk of Crohn's disease (P=0.94). A significant inverse association was found between obesity and total IBD incidence (RR, 0.76; 95% CI, 0.66-0.88; I2=93.2%), but not between increasing BMI and IBD exacerbation, or between increasing BMI and IBD incidence.
Keyphrases
- ulcerative colitis
- weight gain
- body mass index
- weight loss
- case control
- risk factors
- metabolic syndrome
- insulin resistance
- type diabetes
- chronic obstructive pulmonary disease
- end stage renal disease
- high fat diet induced
- chronic kidney disease
- ejection fraction
- prognostic factors
- adipose tissue
- skeletal muscle
- acute respiratory distress syndrome
- deep learning
- mechanical ventilation