Glioblastoma Genetic Drivers Dictate the Function of Tumor-Associated Macrophages/Microglia and Responses to CSF1R Inhibition.
Rohit RaoRong HanSean OgurekChengbin XueLai Man WuLiguo ZhangLi ZhangJian HuTimothy N PhoenixStephen N WaggonerQ Richard LuPublished in: Neuro-oncology (2021)
Our work identify functionally distinct TAM subpopulations in the growth of different glioma subtypes. Notably, we uncover a potential responsiveness of resistant mesenchymal-like gliomas to combined anti-angiogenic therapy and CSF1R inhibition. These data highlight the importance of characterization of the microenvironment landscape in order to optimally stratify patients for TAM-targeted therapy.
Keyphrases
- end stage renal disease
- stem cells
- ejection fraction
- newly diagnosed
- chronic kidney disease
- high grade
- bone marrow
- prognostic factors
- inflammatory response
- genome wide
- electronic health record
- single cell
- machine learning
- neuropathic pain
- patient reported outcomes
- deep learning
- copy number
- patient reported
- data analysis