Preclinical and Clinical Trials of New Treatment Strategies Targeting Cancer Stem Cells in Subtypes of Breast Cancer.
Natalia LanderosIván CastilloRamón Pérez-CastroPublished in: Cells (2023)
Breast cancer (BC) can be classified into various histological subtypes, each associated with different prognoses and treatment options, including surgery, radiation, chemotherapy, and endocrine therapy. Despite advances in this area, many patients still face treatment failure, the risk of metastasis, and disease recurrence, which can ultimately lead to death. Mammary tumors, like other solid tumors, contain a population of small cells known as cancer stem-like cells (CSCs) that have high tumorigenic potential and are involved in cancer initiation, progression, metastasis, tumor recurrence, and resistance to therapy. Therefore, designing therapies specifically targeting at CSCs could help to control the growth of this cell population, leading to increased survival rates for BC patients. In this review, we discuss the characteristics of CSCs, their surface biomarkers, and the active signaling pathways associated with the acquisition of stemness in BC. We also cover preclinical and clinical studies that focus on evaluating new therapy systems targeted at CSCs in BC through various combinations of treatments, targeted delivery systems, and potential new drugs that inhibit the properties that allow these cells to survive and proliferate.
Keyphrases
- cancer stem cells
- end stage renal disease
- induced apoptosis
- clinical trial
- newly diagnosed
- chronic kidney disease
- cancer therapy
- cell therapy
- ejection fraction
- signaling pathway
- papillary thyroid
- prognostic factors
- peritoneal dialysis
- minimally invasive
- stem cells
- endoplasmic reticulum stress
- radiation therapy
- bone marrow
- patient reported outcomes
- climate change
- oxidative stress
- atrial fibrillation
- human health
- free survival
- childhood cancer
- lymph node metastasis
- combination therapy
- patient reported
- placebo controlled