The Fibrinogen-like Domain of ANGPTL3 Facilitates Lipolysis in 3T3-L1 Cells by Activating the Intracellular Erk Pathway.

Simone BiniValeria PecceAlessia Di CostanzoLuca PolitoAmeneh GhadiriIlenia MinicocciFederica TambaroStella CovinoMarcello ArcaLaura D'Erasmo

Published in: Biomolecules (2022)

ANGPTL3-Fld appears to act as a facilitator of lipolysis in adipocytes, and this effect was driven by a signal mediated by a pathway that is different from the canonical β-adrenergic stimulus.

Keyphrases

adipose tissue
signaling pathway
induced apoptosis
cell cycle arrest
pi k akt
cell proliferation
insulin resistance
endoplasmic reticulum stress
skeletal muscle
reactive oxygen species
oxidative stress