Dendritic cells and monocyte subsets in children with Gaucher disease.
Asmaa M ZahranKhaled SaadAlam-Eldin M AbdallahEman F GadYasser F Abdel-RaheemZeinab Albadry M ZahranEman M Nagiub AbdelsalamAmira ElhoufeyThamer AlruwailiKhaled Hashim MahmoudKhalid I ElsayhPublished in: Pediatric research (2021)
Children with Gaucher disease type 1 (GD1) have significantly reduced total and classical monocyte frequencies, with decreasing percentages for both types of dendritic cells. GD1 children had significantly reduced frequencies of myeloid and plasmacytoid dendritic cells as compared to the controls. The GD1 children also had significant changes in monocyte subsets when compared to the controls. Our results show that monocytes and dendritic cells' significant changes could contribute to immunological abnormalities in pediatric patients with GD1.