Ultra-structural study of the indomethacin-induced apoptosis and autophagy in rat gastric parietal cells.

Sahar Mohamed GebrilYuko ItoEman E Abu-Dief Mahmoud Rezk Abdelwahed HusseinHoda M ElsayedAsmaa Naser MohammadUsama Mohamed AbdelaalKazuhide Higuchi

Published in: Ultrastructural pathology (2020)

Our study indicates that IND treatment could induce gastropathy through time-dependent alterations in the autophagic and apoptotic machinery of PCs. Further studies are needed to examine the underlying molecular mechanisms.

Keyphrases

induced apoptosis
endoplasmic reticulum stress
oxidative stress
cell death
signaling pathway
cell cycle arrest
high resolution