A hypoxia-activated photothermal agent inhibits multiple heat shock proteins for low-temperature photothermal therapy.

Xinhao ZhangShan-Shan Xue Wei PanKaiye WangNa Li Bo Tang

Published in: Chemical communications (Cambridge, England) (2023)

A near-infrared (NIR) organic photothermal agent (PTA) to inhibit three types of heat shock proteins (HSPs) was synthesized, which could be activated under hypoxic conditions for low-temperature photothermal therapy (PTT) of cancer.

Keyphrases

heat shock
photodynamic therapy
drug release
heat stress
heat shock protein
cancer therapy
drug delivery
papillary thyroid
oxidative stress
fluorescence imaging
squamous cell
squamous cell carcinoma
young adults
water soluble