Prognostic association of routinely measured biomarkers in patients admitted to critical care: a systematic review.
Yize I WanAdam B BrayneRyan W HainesZudin A PuthuchearyJohn R ProwlePublished in: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (2020)
Simple regression models have so far proved inadequate for the complexity of data available from routine blood sampling in critical care. Adoption of a direct causal framework may help better assess mechanistic processes, aid design of future studies, and guide clinical decision making using routine data.