Entinostat is a novel therapeutic agent to treat oral squamous cell carcinoma.

Ana Elizia M MarquesCarlos Henrique V do Nascimento FilhoThamara M Marinho BezerraEliete Neves da Silva Guerra Rogerio de Moraes Castilho Cristiane Helena Squarize

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2020)

This study indicates that entinostat is a potential novel therapeutic agent for OSCC by halting tumor proliferation, inducing cytotoxicity and intracellular ROS, and attacking the CSCs.

Keyphrases

reactive oxygen species
cell death
dna damage
signaling pathway
risk assessment
oxidative stress
human health