How statin drugs affect exosomes?
Niloofar SekhavatiElmira NooriMitra AbbasifardAlexandra E ButlerAmir Hossein SahebkarPublished in: Journal of cellular biochemistry (2022)
Statins reduce serum cholesterol and isoprenoids by the inhibition of cholesterol synthesis in the mevalonate pathway. Exosomes are extracellular vesicles (30-200 nm) released by all cells that regulate cell-to-cell communication in health and disease by transferring functional proteins, metabolites and nucleic acids to recipient cells. There are many reports that show an effect of statins on exosomes, from their production and release to their content and performance. In this review, we have summarized existing data on the impact of statins on the biosynthesis, secretion, content, uptake and function of exosomes.
Keyphrases
- mesenchymal stem cells
- cardiovascular disease
- induced apoptosis
- stem cells
- cell therapy
- single cell
- cell cycle arrest
- low density lipoprotein
- healthcare
- public health
- endoplasmic reticulum stress
- mental health
- ms ms
- coronary artery disease
- machine learning
- emergency department
- electronic health record
- bone marrow
- health information
- big data
- adverse drug
- deep learning