Non-Specific Effects of Bacillus Calmette-Guérin: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Gerhard TrunkMaša DavidovićJulia BohliusPublished in: Vaccines (2023)
According to these results, depending on the setting, vaccination with BCG provides time-limited partial protection against non-tuberculosis respiratory infections and may reduce mortality. These findings underline BCG's potential (1) in pandemic preparedness against novel pathogens especially in developing countries with established BCG vaccination programs but limited access to specific vaccines; (2) in reducing microbial infections, antimicrobial prescriptions and thus the development of antimicrobial resistance. There is a need for additional RCTs to clarify the circumstances under which BCG's non-specific protective effects are mediated.
Keyphrases
- antimicrobial resistance
- public health
- sars cov
- systematic review
- coronavirus disease
- mycobacterium tuberculosis
- microbial community
- cardiovascular events
- type diabetes
- emergency department
- pulmonary tuberculosis
- risk assessment
- human health
- gram negative
- climate change
- human immunodeficiency virus
- antiretroviral therapy
- hiv infected
- muscle invasive bladder cancer
- drug induced