Isomer separation and effect of the degree of polymerization on the gas-phase structure of chondroitin sulfate oligosaccharides analyzed by ion mobility and tandem mass spectrometry.
Salomé PoyerChrystel Lopin-BonJean-Claude JacquinetJean-Yves SalpinRegis DanielPublished in: Rapid communications in mass spectrometry : RCM (2018)
This study allows the fast and unambiguous differentiation of CS isomers sulfated at position 6 or 4 for both saturated and unsaturated analogues from MS/MS experiments. In addition, the CCS linear evolution of CS oligomers in function of the degree of polymerization indicates that no folding occurs even for hexasaccharides.
Keyphrases
- tandem mass spectrometry
- liquid chromatography
- ultra high performance liquid chromatography
- high performance liquid chromatography
- ms ms
- simultaneous determination
- gas chromatography
- mass spectrometry
- high resolution mass spectrometry
- solid phase extraction
- high resolution
- single molecule
- molecular docking
- hyaluronic acid
- molecular dynamics simulations