A rat model of FOLFOX-induced neuropathy: effects of oral dimiracetam in comparison with duloxetine and pregabalin.

Di Cesare Mannelli LorenzoMario MarescaLaura MicheliCarlo FarinaMichael W ScherzCarla Ghelardini

Published in: Cancer chemotherapy and pharmacology (2017)

A clinically consistent model of FOLFOX-induced neurotoxicity has been developed in rats. Dimiracetam fully reduced hypersensitivity and neurological alterations showing a relevant profile as anti-neuropathic resource.

Keyphrases

high glucose
drug induced
diabetic rats
oxidative stress
endothelial cells
neuropathic pain
blood brain barrier
postoperative pain
subarachnoid hemorrhage
cerebral ischemia