Deregulation of autophagy under hyperglycemic conditions is dependent on increased lysine 63 ubiquitination: a candidate mechanism in the progression of diabetic nephropathy.

Paola PontrelliAnnarita OrangerMariagrazia BarozzinoChiara DivellaFrancesca ConservaMaria Grazia FioreRoberta RossiMassimo PapaleGiuseppe CastellanoSimona SimoneLuigi LaviolaFrancesco GiorginoDomenico PiscitelliAnna GalloneLoreto Gesualdo

Published in: Journal of molecular medicine (Berlin, Germany) (2018)

In vivo autophagy is deregulated in diabetic patients with renal disease (DN). Accumulation of Lys63 ubiquitinated proteins is associated to autophagy deregulation. Accumulation of Lys63 ubiquitinated proteins correlated with apoptosis activation. Lys63 ubiquitination inhibition abrogated hyperglycemia-induced autophagy and apoptosis.

Keyphrases

endoplasmic reticulum stress
cell death
oxidative stress
cell cycle arrest
diabetic nephropathy
diabetic rats
signaling pathway
high glucose
drug induced