Dynamical modeling of proliferative-invasive plasticity and IFNγ signaling in melanoma reveals mechanisms of PD-L1 expression heterogeneity.

Seemadri SubhadarshiniSarthak SahooShibjyoti DebnathJason A SomarelliMohit Kumar Jolly

Published in: Journal for immunotherapy of cancer (2023)

Our calibrated dynamical model offers a platform to test combinatorial therapies and provide rational avenues for the treatment of metastatic melanoma. This improved understanding of crosstalk among PD-L1 expression, proliferative to invasive transition and IFNγ signaling can be leveraged to improve the clinical management of therapy-resistant and metastatic melanoma.

Keyphrases

dendritic cells
immune response
density functional theory
high throughput
mesenchymal stem cells
replacement therapy
skin cancer
cell therapy