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Comprehensive Study on Thiadiazole-Based Anticancer Agents Inducing Cell Cycle Arrest and Apoptosis/Necrosis Through Suppression of Akt Activity in Lung Adenocarcinoma and Glioma Cells.

Gulsen Akalin CiftciBelgin SeverMehlika Dilek Altintop
Published in: Turkish journal of pharmaceutical sciences (2019)
According to in vitro and docking studies, compounds 3 and 8 stand out as promising antiglioma agents.
Keyphrases
  • cell cycle arrest
  • cell death
  • pi k akt
  • signaling pathway
  • cell proliferation
  • molecular dynamics
  • oxidative stress
  • molecular dynamics simulations
  • endoplasmic reticulum stress