Ru-Catalyzed Selective C(sp3 )-H Monoborylation of Amides and Esters.

A ruthenium-catalyzed method has been developed for the C(sp3 )-H monoborylation of various unactivated alkyl and aryl amides and challenging esters, with a low-cost and bench-stable boron source, providing boronates with exclusive selectivity, high efficiency, and high turnover number (up to 8900). This novel strategy may offer a versatile and environmentally friendly alternative to current methods for selective C(sp3 )-H borylation that employ even more expensive metals, such as iridium and rhodium.