Aruncus dioicus var. kamtschaticus Extract Ameliorates Psoriasis-like Skin Inflammation via Akt/mTOR and JAK2/STAT3 Signaling Pathways in a Murine Model.
Banzragch DorjsembeHaneul JooChu Won NhoJungyeob HamJin-Chul KimPublished in: Nutrients (2022)
Goat's beard ( Aruncus dioicus var. kamtschaticus ) is a traditional medicinal plant, widely used in Chinese and Korean traditional medicine because of its anti-inflammatory, anti-oxidant, antimicrobial, and anti-cancer activity. However, its effect on skin inflammatory diseases like psoriasis is unknown. The aim of this study was to investigate the therapeutic potency of A. dioicus extract (ADE) in in vitro and in vivo psoriasis models. ADE treatment significantly attenuated skin inflammation and improved skin integrity in imiquimod-treated mice by suppressing keratinocyte hyperproliferation, inhibiting the infiltration of immune cells, and downregulating the expression of psoriatic markers. Further, ADE treatment suppressed protein kinase B/mammalian target of rapamycin (Akt/mTOR) and Janus kinase 2/signal transducers and activators of transcription 3 (JAK2/STAT3) signaling in HaCaT cells. Overall, the application of ADE relieves psoriasis-like skin inflammation possibly by regulating the Akt/mTOR and JAK2/STAT3 signaling pathways, making it an effective alternative for psoriasis therapy.
Keyphrases
- signaling pathway
- oxidative stress
- cell proliferation
- induced apoptosis
- soft tissue
- anti inflammatory
- wound healing
- protein kinase
- pi k akt
- atopic dermatitis
- epithelial mesenchymal transition
- rheumatoid arthritis
- cell cycle arrest
- metabolic syndrome
- mouse model
- adipose tissue
- tyrosine kinase
- cell death
- bone marrow
- mesenchymal stem cells
- disease activity
- wild type
- cell therapy
- binding protein