Effects of avitinib on the pharmacokinetics of osimertinib in vitro and in vivo in rats.

Qingjun WuHui JiangShuanghu WangDapeng DaiFeifei ChenDeru MengPeiwu GengHongfeng TongYunfang ZhouDebiao PanQuan ZhouChunjie Wang

Published in: Thoracic cancer (2020)

For the first time, we systematically investigated the effect of avitinib, one newly developed third-generation EGFR-TKI, on the pharmacokinetics of osimertinib both in vitro and in vivo using a rat model.

Keyphrases

epidermal growth factor receptor
small cell lung cancer
advanced non small cell lung cancer
tyrosine kinase
atomic force microscopy
high resolution