The attenuation effect of potassium 2-(1-hydroxypentyl)-benzoate in a mouse model of diabetes-associated cognitive decline: The protein expression in the brain.
Wenwen YuHuajing YinYingni SunSi ShiJiang LiXiao-Liang WangPublished in: CNS neuroscience & therapeutics (2022)
These results indicate that dl-PHPB may play a potential role in diabetes-associated cognitive impairment through PI3K/Akt/GSK-3β signaling pathway and the differentially expressed proteins may become putative therapeutic targets.
Keyphrases
- pi k akt
- cognitive decline
- signaling pathway
- cognitive impairment
- type diabetes
- mild cognitive impairment
- mouse model
- cell cycle arrest
- cardiovascular disease
- cell proliferation
- glycemic control
- induced apoptosis
- epithelial mesenchymal transition
- resting state
- functional connectivity
- adipose tissue
- insulin resistance
- brain injury
- cerebral ischemia