Dual activation of estrogen receptor alpha and glucocorticoid receptor upregulate CRTh2-mediated type 2 inflammation; mechanism driving asthma severity in women?
Meerah VijeyakumaranMohdWessam Al JawhriJenna FortunatoLauren SolomonNami Shrestha PalikheHarissios VliagoftisLisa CameronPublished in: Allergy (2022)
Women with severe asthma had higher levels of circulating Th2 cells than men, which may be due to estrogen modifying the effects of GC, enhancing Th2 cell survival and type 2 cytokine production.
Keyphrases
- estrogen receptor
- induced apoptosis
- oxidative stress
- chronic obstructive pulmonary disease
- polycystic ovary syndrome
- cell cycle arrest
- type diabetes
- adipose tissue
- endoplasmic reticulum stress
- signaling pathway
- pregnant women
- cell death
- air pollution
- insulin resistance
- pi k akt
- breast cancer risk
- allergic rhinitis
- gas chromatography
- cervical cancer screening