Interleukin 17A Contributes to Blood-Brain Barrier Disruption of Hypothalamic Paraventricular Nucleus in Rats With Myocardial Infarction.

Published in: Journal of the American Heart Association (2024)

Collectively, these data indicate that BBB permeability within the PVN is enhanced in HF and is likely attributable to increased interleukin 17A/interleukin 17 receptor A signaling in the BBB endothelium, by promoting caveolar transcytosis and degradation of tight junction complexes.

Keyphrases

blood brain barrier
cerebral ischemia
heart failure
nitric oxide
electronic health record
left ventricular
endothelial cells
big data
machine learning
artificial intelligence
atrial fibrillation
deep learning
subarachnoid hemorrhage