EEF1A2 promotes HIF1A mediated breast cancer angiogenesis in normoxia and participates in a positive feedback loop with HIF1A in hypoxia.

Saket Awadhesbhai PatelMd Khurshidul HassanMonali NaikNachiketa MohapatraPoornima BalanPurna Sai KorrapatiManjusha Dixit

Published in: British journal of cancer (2023)

EEF1A2 exhibits angiogenic potential in both normoxic and hypoxic conditions, underscoring its dual role in promoting EMT and angiogenesis, rendering it a promising target for cancer therapy.

Keyphrases

endothelial cells
cancer therapy
vascular endothelial growth factor
drug delivery
epithelial mesenchymal transition
transcription factor
wound healing
young adults