SC5005 dissipates the membrane potential to kill Staphylococcus aureus persisters without detectable resistance.
Chieh-Hsien LuChung-Wai ShiauYung-Chi ChangHsiu-Ni KungJui-Ching WuChui-Hian LimHui-Hui YeoHan-Chu ChangHan-Sheng ChienSheng-Hsuan HuangWei-Kang HungJun-Rong WeiHao-Chieh ChiuPublished in: The Journal of antimicrobial chemotherapy (2021)
Because of its low propensity for resistance development and potent persister-eradicating activity, SC5005 is a promising lead compound for developing new therapies for biofilm-related infections caused by S. aureus.