A novel PET probe to selectively image heat shock protein 90α/β isoforms in the brain.

Takayuki SakaiAya OgataHiroshi IkenumaTakashi YamadaSaori HattoriJunichiro AbeShinichi ImamuraMasanori IchiseMari TadaAkiyoshi KakitaHiroko KoyamaMasaaki SuzukiTakashi KatoKengo ItoYasuyuki Kimura

Published in: EJNMMI radiopharmacy and chemistry (2024)

C]BIIB021 and in vitro and in vivo imaging HSP90α/β. However, the quantification of HSP90α/β is complicated by the presence of radiometabolites in the brain and the potential to be a substrate for p-glycoprotein. Further efforts are needed to develop radioligand suitable for imaging of HSP90α/β.

Keyphrases

heat shock protein
heat shock
high resolution
resting state
white matter
computed tomography
quantum dots
multiple sclerosis
machine learning
risk assessment
quality improvement
human health
living cells
fluorescence imaging
photodynamic therapy
mass spectrometry
fluorescent probe