Tumor CEMIP drives immune evasion of colorectal cancer via MHC-I internalization and degradation.

Biying ZhangJiao LiQingling HuaHaihong WangGuojie XuJiayuan ChenYing ZhuRuiqi LiQing LiangLanqing WangMin JinJing TangZhenyu LinLei ZhaoDejun ZhangDandan YuJinghua RenTao Zhang

Published in: Journal for immunotherapy of cancer (2023)

Overall, our study unveils a novel regulatory mechanism of MHC-I on tumor cell surfaces by CEMIP-mediated internalization and degradation. Furthermore, targeting CEMIP provides an effective strategy for colorectal cancer immunotherapy.

Keyphrases

single cell
transcription factor
cell therapy
stem cells
cancer therapy
escherichia coli
pseudomonas aeruginosa
bone marrow
candida albicans