Liver-secreted FGF21 induces sarcopenia by inhibiting satellite cell myogenesis via klotho beta in decompensated cirrhosis.
Da ZhouYifan ShiDonghua ZhangJunbo ZuoChenghao ZengGulsudum MamtawlaLongChang HuangXuejin GaoLi ZhangXinying Wang
Published in: Redox biology (2024)
Hepatocyte-derived FGF21 mediates liver-muscle crosstalk, which impairs muscle regeneration via the inhibition of the PI3K/Akt pathway, thereby demonstrating a novel therapeutic strategy for DC-related sarcopenia.