Immunological Correlates of the HIV-1 Replication-Competent Reservoir Size.
Sherazaan D IsmailCatherine RiouSarah B JosephNancie M ArchinDavid M MargolisAlan S PerelsonTyler CassidyMelissa-Rose AbrahamsMatthew MoeserOlivia D CouncilLyle R McKinnonFarzana OsmanQuarraisha Abdool KarimSalim S Abdool KarimRonald SwanstromCarolyn WilliamsonNigel J GarrettWendy A BurgersPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
Understanding what shapes the latent human immunodeficiency virus type 1 (HIV-1) reservoir is critical for developing strategies for cure. We measured frequency of persistent HIV-1 infection after 5 years of suppressive antiretroviral therapy initiated during chronic infection. Pretreatment CD8+ T-cell activation, nadir CD4 count, and CD4:CD8 ratio predicted reservoir size.